Principal Computational Biologist

statistical modelling, rna therapy, computational biology
£75000 - £90000 per annum

Principal Computational Biologist

£75-90,000 salary DOE

Mostly remote (must be UK resident and able to commute to London once or twice a month)

Full-time, permanent

Principal Computational Biologist Profile

We are looking for an exceptional Principal Computational Biologist to join their growing team on an exciting journey to support the development of advanced RNA therapeutics addressing critical healthcare challenges.

You will lead advanced modelling methods, with a focus on generating novel target recommendations, validating them in models, and translating them into RNA therapeutics.

Principal Computational Biologist key responsibilities:

- Lead the 'advanced modelling' workstreams, and be the point of contact and a role model for advanced modelling within the company.

- Maintain strong domain knowledge of leading 'omic and 'big data' computational methods

- Drive experimental design & modelling of phenotyping and/ or omics data in close collaboration with wet-lab scientists.

- Work as a member of cross-functional teams bringing together best-in-class Drug Discovery, Drug Development, Product & Project Management capabilities.

- Routinely use Python/R for data analyses, in particular data wrangling, modelling and visualisation.

- Develop solutions to increase automation, reliability and scalability of our data processing pipelines and workflows.

- Lead, co-develop, and run pipelines in a cloud computing environment. Maintain progress in personal and professional development to better domain, technical, and professional skills.

- Contribute to documenting processes and code in the form of SOPs.

- Present research updates to project teams and to the management team.

- Contribute to training initiatives to foster a data-driven culture.

Principal Computational Biologist Qualifications & Experience:


- PhD in computational biology or related PhD

- Experience in delivering results in a fast-paced environment (biotech / pharma industries would be an advantage)

- Strong experience in developing and modifying statistical (and ML) models of 'omics datasets for biological interpretation and actionable insights

- Strong experience with experimental design, exploratory data analysis, reporting and visualisation of data.

- Experience in leading projects involving multiple stakeholders, end-to-end.


- Experience in leading people and delivering through others

- Experience with pipelines / reproducible scientific workflows development (i.e. Nextflow, CodeOcean)

Skills & Competencies


- Deep understanding of human biology beyond the statistical/ML models being developed

- Good knowledge with rapidly prototyping, writing and maintaining Python and/or R code, harnessing statistical tools for biological interpretations.

- Embracing change - this is a fast-growing start-up and change is inevitable!


- Familiarity with project management tools (SmartSheet / JIRA/ ClickUp)Familiarity with Github.

- Familiarity with imaging MLFamiliarity with cloud computing (AWS)

If this role sounds of interest, and you're looking to change the face of RNA therapeutics and deliver meaningful change, then please apply right away to be considered.

Similar Jobs

£75000 - £85000 per annum
Field Applications & Service Manager £75-85k DOE London Are you ready to take the next step in your career and make a significant impact in the world of commercial biotechnology? This newly created role is pivotal in building their technical field team and the service/support infrastructure necessary to bring their innovative platform to market.
£22000 - £25000 per annum
I am pleased to be working with a global manufacturer of high precision instrumentation, their products are sold in over 50 countries while providing safer and more productive research activities. Their product range are used across a wide range of sectors from Pharmaceutical, Biotech and Research.
€60000 - €70000 per annum
I'm pleased to have partnered with a pioneering chemistry equipment manufacturer as on the world's leading supplier of measuring instruments for surface and interfacial tension, Acting quickly and flexibly, they are always at their customer's doorstep in the research and development laboratories as well as quality control centres of countless industries all over the world.
£30000 - £40000 per annum
Pleased to be recruiting for a pioneering start-up company set to revolutionise gene synthesis as part of their fast-growing expansion in synthetic biology.
£35000 - £40000 per annum
TEC Partners is pleased to have partnered with a pioneering medical device company who is set to pave the way for AI-based automated analysis software to overcome a global crisis affecting millions of lives.
€75000 - €85000 per annum
My client, a forward-thinking medical device company at the forefront of bioelectronic medicine. Their mission is simple, they're set to revolutionise healthcare by developing cutting-edge therapies for individuals battling chronic diseases. With their breakthrough, they have been granted the Breakthrough Device Designation by the United States FDA, enabling accelerated market access for devices addressing life-threatening or irreversibly debilitating conditions.
TEC Partners is pleased to have partnered with a pioneering medical device company dedicated to improving the quality of life for patients through next-generation orthopaedic implant devices. Through events, resources, and patient information, my client aims to empower both medical professionals and patients on their journey to improved orthopedic health.
£35000 - £45000 per annum
Design precision components, manage manufacturing processes, and optimize designs as a Mechanical Design Engineer in our innovative life-science team. Competitive salary, benefits, and career growth opportunities provided.
To oversee and lead the R&D of a medical device via a team of multidisciplinary team of engineers across two sites globally.
£50000 - £60000 per annum + + additional benefits
Exciting opportunity for a Design & Development Engineer in medical devices! Drive innovation, from product design to regulatory compliance. Join a global team with a hybrid work setup and attractive benefits.
€70000 - €80000 per annum + 4 day working week (36hrs)
We're seeking a visionary leader to drive research and development projects in surface analysis technology.
£75000 - £90000 per annum
Principal Computational Biologist £75-90,000 salary DOE Mostly remote (must be UK resident and able to commute to London once or twice a month)